Intranuclear inclusion bodies (IBs) are the histopathologic markers of multiple protein folding diseases.IB formation has been extensively studied using fluorescent fusion products of pathogenic polyglutamine (polyQ) expressing proteins.These studies have been informative in determining the cellular targets of expanded polyQ protein as well as the
In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains.Translational research using a One Health approach provides a fundamental link between basic biomedical research and medic
Summary: Background: Disease burden has been used to predict National Institutes of Health (NIH) funding but included diseases with little underlying relationship.Here we focus on cancers dragon ball lg disney to create a more appropriate model to allow for more targeted scrutinization of funding allocation.Methods: An ecological study using NIH fu
Background/AimsThe long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with click here thiopurine are unclear.The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with thiopurine in UC patients.MethodsThis was a retrospective observational cohort analysis co